Python 

i can't cut and past a block of code for testing into the interactive python due to the stupid indentation

you have to write it pretty and more importantly edit it pretty. it is impossible to have a pretty printer or reformatter for python due to the lack of an end keyword.

i use multiple editors and ide's for developement, quick edits, and editting through a terminal window. i hate having to make sure they all format python the same way.

"use a real editor" is not a valid response to complaints about lack of a closing keyword or indentation.

i have to do extra work to comment out or deactivate a block of code; in other languages i can simply put something like "if false" and "end" around it. In python i have to re-indent or recomment the whole block too.

the indentation aspect makes cutting and pasting code a pain in the arse, and cut/paste is a significant part of coding.